Mabruka Alfaidi, PhD
Dr. Mabruka Alfaidi completed her PhD in Cardiovascular Science at the University of Sheffield, UK and was an Honorary Research Fellow and Outstanding Graduate Award winner. 06/2015- 06/2016 (Mentor: Sheila Francis)
Dr. Alfaidi's research is focused on the molecular mechanisms/processes of the secretion and the signaling pathway(s) of the leaderless cytokine interleukin-1β (IL-1β) and the cells of origin of IL-1β during atherosclerotic plaque formation and, as well as how this is altered in advanced lesions. This is important because the IL-1 signalling pathway has been shown to be causal in coronary artery disease (the CANTOS trial) and this specificity of effect is supported by other recent data from a myriad of related high profile clinical studies. Her studies showed the endothelium as a primary source and target to limit vascular wall inflammation by IL-1 mediated mechanisms. The long term goal of Dr. Alfaidi's research is to elucidate the mechanism by which atherosclerosis develops, focusing on IL-1 signaling within endothelium and to characterize a targeted strategy to locally block IL-1 signaling in coronary heart disease patients.