Mabruka Alfaidi, PhD

Faculty Information

Title(s)
Instructor in Pathology
Areas of Specialty
Vascular wall inflammation, Atherosclerosis, Cardiovascular disease, Molecular biology, Vascular biology

Contact Information

Email
(Primary)

Other Information

Biography

Dr. Mabruka Alfaidi completed her PhD in Cardiovascular Science at the University of Sheffield, UK and was an Honorary Research Fellow and Outstanding Graduate Award winner. 06/2015- 06/2016 (Mentor: Sheila Francis)

Dr. Alfaidi's research is focused on the molecular mechanisms/processes of the secretion and the signaling pathway(s) of the leaderless cytokine interleukin-1β (IL-1β) and the cells of origin of IL-1β during atherosclerotic plaque formation and, as well as how this is altered in advanced lesions. This is important because the IL-1 signalling pathway has been shown to be causal in coronary artery disease (the CANTOS trial) and this specificity of effect is supported by other recent data from a myriad of related high profile clinical studies. Her studies showed the endothelium as a primary source and target to limit vascular wall inflammation by IL-1 mediated mechanisms. The long term goal of Dr. Alfaidi's research is to elucidate the mechanism by which atherosclerosis develops, focusing on IL-1 signaling within endothelium and to characterize a targeted strategy to locally block IL-1 signaling in coronary heart disease patients.