Nobel's Biostatistics & Computational Biology Lab
Mohammad Alfrad Nobel Bhuiyan, PhD
Director, Biostatistics and Computational Biology
Co-Director, Medical Student Research
Sub-Core Leader, Machine Learning and Data Harmonization Core
Assistant Professor, Department of Medicine, Department of Pathology and Translational Pathobiology and
Department of Biochemistry and Molecular Biology
Louisiana State University Health at Shreveport, Louisiana
Phone: 318-675-5968; Fax: 318-675-5969; Email: nobel.bhuiyan@lsuhs.edu
News
Laboratory News
At the Malcolm Feist Symposium in 2026, Anderson DeWitt received first place.
At the Malcolm Feist Symposium in 2026, Claire White won second place.
At the Malcolm Feist Symposium in 2026, Colin Laird won third place.
Dr. Bhuiyan and his students (Colin Laird, Zack Karzoun, and Claire White) received $30,000 summer research grant in 2026.
Oct, 2024 - Dr. Bhuiyan project "Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY)" was funded by Institutional Development Award (IDeA) from theNational Institutes of General Medical Sciences of the NIH under grant number P20GM121307.
Aug, 2024 - Diensn Xing started his PhD in Dr. Bhuiyan's Lab.
May, 2024 - Dr. Bhuiyan named as the Co-Director of "Medical Student Research" at LSU Health Shreveport.
September, 2023 - Dr. Bhuiyan named as the Director of "Biostatistics and Computational Biology" at LSU Health Shreveport.
September, 2023 - Fatih Gelir and MD. Ismail Hossain joined Dr. Bhuiyan's lab as Biostatistician.
July, 2023 - Dr. Bhuiyan UGREP student got the best poster award and Dr. Bhuiyan got the best mentor award.
June, 2023 - Dr. Bhuiyan selected to serve as the Statistical Editor for "Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)" journal.
March, 2023 - Dr. Bhuiyan joined "Frontiers in Epidemiology" Editorial Board.
February, 2023 - Dr. Bhuiyan received "Excellence in Translational Research" Award, 2023.
February, 2023 - Dr. Bhuiyan's students secured 1st (Tyler Pierotti ) and 2nd place (Zaki Al Yafeai) in the CCDS Feist Cardiovascular Research Symposium.
December, 2022 - Dr. Bhuiyan was invited to serve as a Statistical Editor for the Journal of American heart Association (JAHA). This position is competitive and selected by the chief editor to perform this role.
December, 2022 - Taymaz Akan, PhD joined Dr. Bhuiyan's Lab as a Postdoctoral fellow.
September, 2022 - Dr. Bhuiyan has been selected as an Institutional Review Board (IRB) Member.
July, 2022 - Abu Saleh Mosa Faisal joined Dr. Bhuiyan's Lab as a Biostatistician.
Research
Nobel's Research
My research focuses on developing and applying advanced mathematical and statistical models to understand complex cardiovascular, neurobehavioral, and metabolic diseases. I combine standard biostatistics with new techniques like machine learning, deep learning, and image processing to study various types of data, such as electronic health records, medical images (like MRI and digital pathology), and complex biological data.
By building predictive and mechanistic models of disease risk, progression, and treatment response, my lab aims to improve early diagnosis, refine patient stratification, and advance precision medicine. We develop novel algorithms and AI-driven pipelines for image analysis, data harmonization, and biomarker discovery, with a particular emphasis on cardiovascular disease and Alzheimer’s disease.
Ongoing and Recently Completed Projects
Healthy Americas Foundation (Active)
Bhuiyan, Mohammad Alfrad Nobel, Role: PI
Title: Develop a Polygenic Risk Score for Intracranial Aneurysm
01/01/2026-06/30/2026
P20GM121307 (Active)
Bhuiyan, Mohammad Alfrad Nobel, Role: Research Project Leader
Title: Redox, Environmental, and Metabolomics: Investigating Disease Yield (REMEDY)
9/17/2024-6/30/2027
EPSCoR CREST Phase I, NSF (Active)
Mohammad Alfrad Nobel Bhuiyan, Role: Sub-Core Director
10/1/2025- 09/30/2031
Center for Post-Transcriptional Regulation (CPTR)
R01HL172970 (Active)
Bhuiyan, Md. Shenuarin (PI), Role: Co-In
6/7/2024-5/31/2029
Title: Novel mitophagy regulatory mechanism in heart failure
R01AI179608 (Active)
Ana Maria Dragoi (PI), Role: Co-In
5/16/2024-3/31/2029
Title: Mechanism of macrophage colonization in gonorrhea
R01HL143074 NHLBI (Active)
Lal, Hind (PI), Role: Co-In
6/7/2022-5/31/2027
Title: Novel Mechanisms of Cardiac Function and Dysfunction
Publications
Nobel's Publications
- Scardino B, Agrawal A, Xing DG, St. Pierre JL, Bhuiyan MM, Kamronnaher K, Bhuiyan MS, Rom O, Conrad SA, Vanchiere JA, Orr AW, Bhuiyan MAN. Clustering environmental pollutants associated with increased risk of metabolic disease: a hierarchical analysis. Health Information Science and Systems. 2025 Sep 24;13(1):59.
- Akan T, Akan S, Alp S, Ledbetter CR, Bhuiyan MAN, AlzFormer: Video-based space-time attention model for early diagnosis of Alzheimer’s disease. Neuroscience. 2025 Sep 3.
- Akan T, Alp S, Bhuiyan MS, Disbrow EA, Conrad SA, Vanchiere JA, Kevil CG, Bhuiyan MAN. An artificial intelligence-based framework for Alzheimer’s disease diagnosis from magnetic resonance imaging volumes via video vision transformer. Intelligent Medicine. 2025 Aug 6.
- Akan T, Alp S, Bhuiyan MS, Helmy T, Orr AW, Bhuiyan MM, Conrad SA, Vanchiere JA, Kevil CG, Bhuiyan MAN. ViViEchoformer: deep video regressor predicting ejection fraction. Journal of imaging informatics in medicine. 2025 Aug;38(4):2041-52.
- Kaur H, Pandey N, Chandaluri L, Shaaban N, Kumar D, Pandit R, Martinez A, Anand SK, Das S, Bhuiyan MAN, Rohilla S, Arias F. Neutrophil Integrin α9 Impairs Efferocytosis and Worsens Long-Term Recovery After Subarachnoid Hemorrhage. Arteriosclerosis, Thrombosis, and Vascular Biology. 2025 Jul 31.
- Sait A, Sara A, Taymaz A, Bhuiyan MAN, MRI-based Alzheimer’s disease classification using Vision Transformer and time-series transformer: A step-by-step guide, Software Impacts, Volume 25,2025.
- Farishta D, Shires CB, Dewan K, Knackstedt M, Soleja R, Bundrick P, Bhuiyan MAN, Sanders K, Nathan CA. Trends in Cosmetic Facial Plastic Surgery Post COVID-19 Pandemic. Plastic and Reconstructive Surgery–Global Open. 2025 Jul 1;13(7):e6950.
- Agrawal A, Scardino B, Xing DG, Bhuiyan MS, Bevins RA, Modi K, Helmy T, Conrad SA, Goeders NE, Bhuiyan , Vanchiere JA, Bhuiyan MAN Hospitalized Patients and Stimulant Use-Associated Heart Failure: Import of Ejection Fraction and Related Risk Factors. Frontiers in Cardiovascular Medicine.;12:1566481.
- Scardino B, Dicharry D, Agrawal A, Xing D, Bhuiyan MM, Bhuiyan MS, Rom O, Conrad SA, Vanchiere JA, Orr AW, Kevil CG, Bhuiyan MAN. Cumulative environmental exposures and metabolic syndrome: A study of heavy metals and volatile organic compounds. Ecotoxicology and Environmental Safety. 2025 Jun 1;297:118238.
- Boullion J, Husein A, Agrawal A, Xing D, Hossain MI, Bhuiyan MS, Rom O, Conrad SA, Vanchiere JA, Orr AW, Kevil CG, Bhuiyan MAN. Machine Learning-Based Biomarker Identification for Early Diagnosis of Metabolic Dysfunction-Associated Steatotic Liver Disease. The Journal of Clinical Endocrinology & Metabolism. 2025 Feb 21:dgaf111.
- Thapa M, Courville J, Leonhard R, Buchhanolla P, Sheikh MA, Shah R, Rai P, Chokhawala H, Hossain MI, Bhuiyan MAN, Jordan JD. The Correlation of Whole Blood Viscosity and Outcome in Mechanical Thrombectomy for Acute Ischemic Stroke. Frontiers in Stroke.;4:1517343.
- Kelley RE, Buchhanolla P, Pandey A, Thapa M, Hossain MI, Bhuiyan MAN. Diagnostic yield and therapeutic implications of vascular imaging in acute ischemic stroke: prospective and consecutive study of small vessel versus large vessel ischemia. Journal of Stroke and Cerebrovascular Diseases. 2025 Feb 1;34(2):108182.
- Akan T, Alp S, Bhuiyan MS, Disbrow EA, Conrad SA, Vanchiere JA, Kevil CG, Bhuiyan MAN. Leveraging Video Vision Transformer for Alzheimer's Disease Diagnosis from 3D Brain MRI. arXiv preprint arXiv:2501.15733. 2025 Jan 27.
- Ali S, Khlidj Y, Kumar M, Alsaeed T, Farooq F, Keisham B, Bhuiyan MAN, Ponna PK, Duhan S, Brar V, Manan M, Khan MR. Impact of kidney disease in patients undergoing catheter directed interventions for intermediate to high-risk pulmonary embolism. The American Journal of the Medical Sciences. 2025 Jan 7.
- Husein A, Bouillon J, Hossain MI, Xing D, Khan MT, Kolluru GK, Bhuiyan MM, Goeders NE, Conrad SA, Vanchiere JA, Orr AW, Bhuiyan MAN. Trends and Patterns in Pulmonary Arterial Hypertension-Associated Hospital Admissions among Methamphetamine Users: A Decade-Long Study. Frontiers in Cardiovascular Medicine.;11:1445193.
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Xing DG, Mohiuddin F, Bhuiyan MS, Hossain MI, Al-Yafeai Z, Mosa Faisal AS, Goeders NE, Conrad SA, Vanchiere JA, Patterson JC, Kevil CG Bhuiyan MAN. Prevalence and patterns of methamphetamine use and mental health disparity in the United States. Nature Mental Health. 2024 Jun 26:1-9.
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Alp S, Akan T, Bhuiyan MAN. Transferring knowledge: CNNs in Martian surface image classification. Artificial Intelligence: Machine Learning, Convolutional Neural Networks and Large Language Models. 2024 Aug 5;1:71.
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Alp S, Akan T, Bhuiyan MS, Disbrow EA, Conrad SA, Vanchiere JA, Kevil CG, Bhuiyan MAN. Joint transformer architecture in brain 3D MRI classification: its application in Alzheimer’s disease classification. Scientific Reports. 2024 Apr 18;14(1):8996.
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Akan T, Oskouei AG, Alp S, Bhuiyan MAN. Brain magnetic resonance image (MRI) segmentation using multimodal optimization. Multimedia Tools and Applications. 2024 Jul 2:1-50.
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Akan S, Varlı S, Bhuiyan MAN*. An enhanced Swin Transformer for soccer player reidentification. Scientific Reports. 2024 Jan 11;14(1):1139.
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Akan T, Alp S, Bhuiyan MAN. Vision Transformers and Bi-LSTM for Alzheimer's Disease Diagnosis from 3D MRI. In2023 Congress in Computer Science, Computer Engineering, & Applied Computing (CSCE) 2023 Jul 24 (pp. 530-535). IEEE.
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Bonin BJ, Beckman S, Diaz R, Terrell D, Mahmud S, Bhuiyan MAN, Kumbhare D, Savardekar A, Guthikonda B. The Utility of Stereotactic Radiosurgery in Primary Treatment of Small to Medium Sporadic Vestibular Schwannomas: A Systematic Review and Meta-Analysis. Journal of Neurological Surgery Part B: Skull Base. 2024 Feb;85(S 01):S146.
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Al-Yafeai Z, Ali S, Brown J, Venkataraj M, Bhuiyan MS, Faisal AS, Densmore K, Goeders NE, Bailey SR, Conrad SA, Vanchiere JA, Bhuiyan MAN. Cardiomyopathy-associated hospital admissions among methamphetamine users: geographical and social disparities. JACC: Advances. 2024 Mar 13:100840.
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Akan T, Sait Alp, Bhuiyan MAN, ECGformer: Leveraging transformer for ECG heartbeat arrhythmia classification, IEEE Computer Science, Computer Engineering, & Applied Computing (CSCE),
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Alp S, Dehkharghani R, Akan T, Bhuiyan MAN. MOBRO: multi-objective battle royale optimizer. The Journal of Supercomputing. 2024 Mar;80(5):5979-6016. 2024
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Akan T, Oliva D, Feizi-Derakhshi AR, Feizi-Derakhshi AR, Pérez-Cisneros M, Bhuiyan MAN. Battle royale optimizer for multilevel image thresholding. The Journal of Supercomputing. 2024 Mar;80(4):5298-340.
TEAM
Taymaz Akan, PhD
Postdoctoral Fellow
Taymaz Akan is a Postdoctoral Fellow in Bhuiyan's lab. He received his Ph.D. from the Department of Computer Engineering at Gazi University, Ankara, Turkey in 2019. He is experienced on image processing and optimization algorithms. His research focus is to optimize MRI images and develop disease progression model.
Niels Dickson, PhD
Postdoctoral Fellow
Niels Dickson is a Postdoctoral Fellow working with Dr. Bhuiyan and Dr. Chen Lin (Neurology). He earned his PhD in Language Science from the University of California, Irvine, where his research focused on computational models of language acquisition and cognitive theories of learning. Through this work, he developed expertise in probabilistic modeling, machine learning, and language modeling, including large language models (LLMs). Dr. Dickson’s current research focuses on developing and applying computational and machine‑learning models to clinical problems. His work emphasizes integrating modern LLM architectures with statistical modeling to improve risk assessment, outcome prediction, and clinical decision‑support tools.
Mohammad Nahian Abrar, PhD
Biostatistician
Mohammad Nahian Abrar, PhD, is a Biostatistician with expertise in high-dimensional omics data analysis for the identification of genetic and epigenetic biomarkers associated with human disease. His work experience spans statistical methodology for omics studies, R package development, and applied research in epigenetics, mediation analysis, and longitudinal modeling of sepsis readmission. Dr. Abrar earned his PhD in Biostatistics and Epidemiology from the University of Memphis. His current research focuses on biomedical research applications, predictive modeling, and the development of analytical pipelines that support physicians in disease risk assessment and clinical decision-making.
Diensn Xing
MD-PhD Student
Diensn Xing is a dedicated MD-PhD student with a background in biological engineering, having previously researched breast cancer as an undergraduate at LSU A&M. He has a strong interest in internal medicine and population health and has already contributed to peer-reviewed publications highlighting the trends in demographic disparities in mental health and substance use disorders. Recognized for both academic excellence and leadership, he has been inducted into the Alpha Omega Alpha and Gold Humanism Honor Societies. Beyond the lab, Diensn provides primary care at a community health clinic weekly, demonstrating his commitment to service and direct patient care. Outside of medicine, he enjoys volleyball, making music, and competitive esports, reflecting his diverse interests and holistic approach to life.
Current Students
Anderson DeWitt
MS2
LSU Health Shreveport
Zack Karzoun
MS2
LSU Health Shreveport
Colin Laird
MS1
LSU Health Shreveport
Brooke Scardino
MS3
LSU Health Shreveport
Donovan Turpin
MS2
LSU Health Shreveport
Claire White
MS1
LSU Health Shreveport
Previous Students
Akshat Agrawal
Master of Public Health Program
3rd Semester, Year 2
Jolie Boullion
School of Medicine
Class of 2026
Destyn Dicharry
School of Medicine
Class of 2027
Awards & Recognition
AWARDS & RECOGNITIONS
AHA scientific Session, 2025, New Orleans
AHA scientific Session, 2025, New Orleans with the students of Dr. Bhuiyan's Lab.
Diensn Xing, PhD student, received an award in the 2024 Biomedical Research and Industry Day (BRAID) for his poster “Predicting pulse and blood pressure variation in Methamphetamine users: A novel Approach”
Brooke Scardino
MSRP Student, wins Best Poster Award for
"Characterizing the Demographics, Trends, and Subtypes of Stimulant-Associated Heart Failure by Ejection Fraction"
Ife Shango
UGREP Student wins poster competition for "Using Machine Learning Model to Assess Biomarkers Associated with Stroke in Diabetic Patients"
POSITIONS
Education & Training
Postdoctoral Fellows
We are actively recruiting Postdoctoral Fellows who has experience in Computational Biology, Bioinformatics or Spatial Analysis. Interested candidates can contact Dr. Bhuiyan at Nobel.Bhuiyan@lsuhs.edu.
Statistical Analyst
Interested candidates can contact Dr. Bhuiyan at Nobel.Bhuiyan@lsuhs.edu. Experience in programming language (R, Python etc) required.
CONTACT US
CONTACT US
LSU Heath Shreveport
Department of Internal Medicine
1501 Kings Hwy, Shreveport, LA 71103
O: 318-675-5980
C: 318-286-0262
F: 318-675-7176
Mohammad Alfrad Nobel Bhuiyan, PhD
Assistant Professor
Division of Clinical Informatics
Department of Medicine
Louisiana State University Health Shreveport
BRI F6-28, 1501 Kings Highway, Shreveport LA 71103
Phone: 318-675-5968; Fax: 318-675-5969
Email: nobel.bhuiyan@lsuhs.edu