LSU Health Shreveport
Department of Pharmacology, Toxicology & Neuroscience
1501 Kings Hwy
Shreveport, LA 71103
Nicholas E. Goeders, PhD
Professor and Head of Pharmacology, Toxicology & Neuroscience
Bachelor of Science, Psychology with a minor in Chemistry - LSU-Shreveport
PhD, Pharmacology - LSU Health Shreveport
Post-doctoral Fellow, Neuroscience - Johns Hopkins University School of Medicine, Baltimore
We have been investigating the role for stress and the subsequent activation of the hypothalamo-pituitary-adrenal (HPA) axis in the etiology of drug addiction for several years now and have shown that stress is involved in the acquisition of drug seeking as well as the reinstatement of drug seeking (relapse). We employ a variety of techniques including intravenous drug self-administration, in vivo microdialysis, neurotoxin lesions, and receptor analysis combined with pharmacological, behavioral and environmental interventions. Our ultimate goal is the identification of novel pharmacotherapies based on manipulations of HPA axis and central nervous system activity by translating the results of our preclinical studies into clinical research.
Thus my laboratory has investigated the neurobiology of psychomotor stimulant reinforcement for over 30 years. We have investigated the effects of a variety of pharmacological agents on drug self-administration, and the results of our research have been translated into a successful pilot clinical trial in human cocaine users. This, in turn, led to the founding of a biotech company, Embera NeuroTherapeutics, Inc., that is taking this research into larger clinical trials. A pilot clinical trial was conducted based on my research and was published in 2012 (see below). In addition, this work led to the filing of several patents by Embera, which has licensed the technology from LSU.
Kablinger, A.S., Lindner, M.A., Casso, S., Hefti, F., DeMuth, G., Fox, B.S., McNair, L.A., McCarthy, B.G., and Goeders, N.E. Effects of the Combination of Metyrapone and Oxazepam on Cocaine Craving and Cocaine Taking: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Journal of Psychopharmacology, 26(7):973-981, 2012. PMID: 22236504.
Major Research Accomplishments:
While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered. To enquire about opportunities, contact Dr. Goeders at firstname.lastname@example.org.
Graduate students interested in conducting research in the Goeders lab should review the current laboratory research directions and contact Dr. Goeders at email@example.com.
Undergraduate Research Assistants
We are not currently hiring any additional undergraduates. However, positions can occasionally become available.
Medical Students, Residents, and Fellows
The Goeders laboratory has a number of research projects available for any Medical Students, Residents, and Fellows interested in performing substance abuse research.