Cruz Lab

Contact Us

LSU Health Shreveport
Department of Molecular & Cellular Physiology
1501 Kings Hwy
Shreveport, LA 71103


Office: (318)675-5128
Lab: (318)675-4212
Fax: (318)675-6005

Diana Cruz-Topete, PhD

Assistant Professor of Molecular and Cellular Physiology
Bachelor of Science (2002) - Universidad de Las Americas-Puebla, Cholula, Mexico
PhD, Biochemistry (2008) - University of Notre Dame
Post-Doctoral Fellow, (2011) - Edison Biotechnology Institute
Post-Doctoral Fellow, (2016) - National Institute of Environmental Health Sciences


Congratulations to Shripa Amatya! She has been selected to receive a travel award to attend the Early Career Forum which is held in conjunction with the Endocrine Society's Annual Meeting & Expo. The meeting will be held March 28-31, 2020 in San Francisco. Congratulations Shripa!
Shripa is a graduate assistant in the Cruz Laboratory in the Department of Molecular and Cellular Physiology.


My current research and future plans are focused on the physiology and the molecular mechanisms of action of nuclear receptors; specifically, the sexual dimorphic effects of stress signaling (glucocorticoid receptor) in cardiac health. My long-term goals are: 1) to define the gender-specific effects of stress in the heart; and 2) to elucidate the molecular basis for gender differences in stress-driven heart disease and failure.


Selected Publications

  1. Burford,N.G., Kamberov, L.A.D, Amatya, S., Orr, A.W., Cidlowski, J.A., and Cruz-Topete, D (2019) Glucocorticoid Receptor inhibition of ER- Transcriptional Regulation of Serotonin Receptor 2B in Cardiomyocytes leads to increased Cell Death in response to Hypoxia/Reoxygenation. J Biol Chem. In preparation.
  2. Cruz-Topete, D*, Oakley, R.H., Burford, N.G., Trosclair, K., Watts, N.M., Glasscock, E., Dominic, P., Myers, P.H., Xu, X., and Cidlowski, J.A.* (2019) Deletion of the Cardiomyocyte Glucocorticoid Receptor leads to Sexually Dimorphic Changes in Cardiac Gene Expression and Progression to Heart Failure. JAHA. 2019 Aug 6;8(15):e011012. doi: 10.1161/JAHA.118.011012. Epub 2019 Jul 17.
    *Co-Senior Authors
  3. Oakley RH, Cruz-Topete D, He Bo, Foley FJ, Myers PH, Gomez-Sanchez C, Chambon P, Willis MS, Cidlowski JA. Imbalanced Stress Signaling in Cardiomyocytes Regulates Heart Disease. Science Signaling 2019. 2019 Apr 16;12(577). pii: eaau9685. doi: 10.1126/scisignal.aau9685.

Complete List of my Published Work in MyBibliography: LEARN MORE


Natalie Burford

Research Associate

Shripa Amatya

Graduate Assistant


Post-doctoral Fellows

While we are not currently recruiting Post-doctoral Fellows, quality candidates will always be considered.  To enquire about opportunities, contact Dr. Cruz at

Graduate Students

Graduate students interested in conducting research in the Cruz lab should review the current laboratory research directions and contact Dr. Cruz at

Undergraduate Research Assistants

We are not currently hiring any additional undergraduates. However, positions can become available during the summer.

Medical Students, Residents, and Fellows

The Cruz laboratory has a number of research projects available for any Medical Students, Residents, and Fellows. Those interested in learning more about research opportunities in the Cruz lab should contact Dr. Cruz directly at