Matthew D. Woolard, PhD
Associate Professor of Microbiology and Immunology
Bachelor of Arts, Biology - Austin College
PhD, Biomedical Sciences - University of North Texas Health Science Center at Fort Worth
Post-Doctoral Fellow - University of North Carolina at Chapel Hill
Matthew D. Woolard, PhD, Associate Professor of Microbiology and Immunology, is the first holder of the O’Callaghan Family Endowed Professorship in Microbiology.
2019 - Matthew Woolard, PhD will serve as a Co-Investigator with the CURIOUS Program. Cardiovascular Undergraduate Research Initiative for Underrepresented Students (CURIOUS) is a summer program at LSU Health Shreveport funded by an R25 Research Education Program grant (R25HL147665) from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI). This summer research program is hosted by the Center for Cardiovascular Diseases and Sciences (CCDS) and is designed to provide an educational and hands-on research opportunity for underrepresented undergraduate students who are interested in pursuing research as part of their scientific or clinical career goals.
Major Research Interests:
Lipid metabolic regulation of macrophage function that contributes to disease pathogenesis.
Macrophages are heterogeneous cells of the immune system that contribute to antibacterial activity, tissue homeostasis, resolving inflammation and wound healing. Carrying out these diverse roles requires functional plasticity. This also means this plasticity can be disrupted resulting in the contribution of macrophage activity to the pathogenesis of numerous diseases. Lipid metabolism and lipid mediated signaling are crucial to the regulation of macrophages function. The goal of my laboratory is to understand how lipid metabolic enzymes contribute to macrophage function during disease. We are investigating how lipid metabolism by macrophages during atherosclerosis contributes either promotion or resolution of atherosclerotic lesion formation. A better understanding of these processes will likely identify new molecular target for the development of therapies to treat CVD.
- Vozenilek AE, Blackburn CMR, Schilke RM, Chandran S, Castore R, Klein RL, Woolard MD. 2018. AAV8-mediated overexpression of mPCSK9 in liver differs between male and female mice. Atherosclerosis. 278:66-72. PMID 30253291
- Vozenilek AE, Navratil AR, Green JM, Coleman DT, Blackburn CMR, Finney AC, Pearson BH, Chrast R, Finck BN, Klein RL, Orr AW, Woolard MD. 2018. Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis. Arterioscler Thromb Vasc Biol 38(2):324-334. PMID:29217509 PMCID:PMC5785462
- Navratil AR, Vozenilek AE, Cardelli JA, Green JM, Thomas MJ, Sorci-Thomas MG, Orr AW, Woolard MD. 2015. Lipin-1 Contributes to Modified Low-Density Lipoprotein-Elicited Macrophage Pro-Inflammatory Responses. Atherosclerosis 242(2):424-32. PMID:26288136 PMCID:PMC4712446
Postdocs: We are not actively recruiting postdoctoral fellows, but qualified candidates will be considered. Inquiries should be directed to Dr. Woolard.
Graduate students: Students interested in working in our Department should visit our Graduate Program website: https://www.lsuhscshreveport.edu/departments/school-of-graduate-studies/microbiology-and-immunology/graduate-program
Undergraduate students: Our Undergraduate Biomedical Research Fellowship program provides bright undergraduates a chance to gain hands-on research experience through a paid internship. More information can be found here: https://www.lsuhscshreveport.edu/departments/school-of-graduate-studies/microbiology-and-immunology/undergraduate-fellowship