LSU Health Shreveport
Department of Microbiology & Immunology
1501 Kings Hwy
Shreveport, LA 71103
Med School B 2-213
Med School B 2-241
Jason Bodily, PhD
Assistant Professor of Microbiology and Immunology
Bachelor of Science - Brigham Young University
PhD in Microbiology - Penn State University Hershey Medical Center
Post-Doctoral Fellow - Northwestern University Feinberg School of Medicine
Dr. Sadie Rice graduated with her PhD in Microbiology on May 13, 2020
Dr. Matthew Scott graduated with his PhD in Microbiology on April 25, 2019.
The laboratory was awarded a Center of Excellence in Arthritis and Rheumatology (CEAR) Research Award to better understand how signals from the stromal microenvironment suppress HPV replication in infected epithelia.
Major Research Interest
Human Papillomaviruses (HPVs)
Human papillomaviruses (HPVs) are the causative agents of cervical and other cancers. As part of their normal life cycles, these small DNA viruses infect stratified epithelia and establish persistent infections, usually resulting in minor hyperproliferation, but occasionally progressing to malignancy. The goal of the laboratory is understand the evolved functions of HPV oncogenes in sustaining persistent, productive viral infection and how those functions are dysregulated during cancer development. We can model all phases of the viral life with both wild-type and genetically modified viruses using a variety of cell culture techniques, including organotypic culture, to establish persistent HPV infections in vitro.
We have discovered that the HPV oncogenes E5 and E7 regulate overlapping sets of genes that regulate the interaction between infected epithelia and cells of the stromal microenvironment, with particular impact on innate immunity. We have discovered that signals from stromal fibroblasts are critical for controlling HPV infection in the epithelium. Current work in the laboratory explores the molecular mechanisms behind this regulation and how these and other interactions facilitate the viral life cycle and set the stage for cancer development.
- JM Bodily and C Meyers. Genetic Analysis of the Differentiation-dependent HPV31 Late Promoter. Journal of Virology, 79(6):3309-21, 2005. PMC1075705
- S Alam, J Bromberg-White, M McLaughlin-Drubin, E Sen, JM Bodily, and C Meyers. Activity and Therapeutic Potential of ORI-1001 Antisense Oligonucleotide on Human Papillomavirus Replication Utilizing a Model of Dysplastic Human Epithelium. Anticancer Research, 25:765-78, 2005.
- JM Bodily, S Alam, and C Meyers. Regulation of Human Papillomavirus Type 31 Late Promoter Activation and Genome Amplification by Protein Kinase C. Virology, 348(2):328-40, 2006.
- JM Bodily*, M Nakamura*, M. Beglin, S Kyo, M Inoue, LA Laimins. Hypoxia-specific stabilization of HIF-1α by human papillomaviruses. Virology, 387(2):442-8, 2009. PMC2674135 *Co-first authors
- TJ McGarry, M Bonaguidi, L Lyass, JA Kessler, JM Bodily, L Doglio. Enucleation of feeder cells and egg cells with psoralens. Developmental Dynamics, 238:2614-2621, 2009 PMC2885919
- JM Bodily, KPM Mehta, and LA Laimins. Human papillomavirus E7 enhances hypoxia inducible factor-1 mediated transcription by inhibiting binding of histone deacetylases. Cancer Research 71:1187-95, 2011. PMC3077548
- JM Bodily, KPM Mehta, L Cruz, C Meyers, and LA Laimins. The E7 Open Reading Frame Acts in Cis and Trans to Mediate Differentiation-Dependent Activities in the Human Papillomavirus Type 16 Life Cycle. Journal of Virology, 85(17):8852-62, 2011. PMC3165838
- M Donaldson, L Mackintosh, JM Bodily, E Dornan, L Laimins, and I Morgan. An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment. Journal of Virology, 86(23):12806-15, 2012, PMC3497701. PMC3497701
- JM Bodily*, GA Wrobel, C Hennigan, and CM Rodriguez. Regulation of the human papillomavirus type 16 late promoter by E7 and the cell cycle. Virology 433(1):11–19, 2013 (Featured in Virology Highlights Blog). PMC5789804 *senior author
- EJ Gauson, MM Donaldson, ES Doran, X Wang, M Bristol, JM Bodily, and IM Morgan. Evidence supporting a role for TopBP1 and Brd4 in the initiation but not continuation of human papillomavirus 16 E1/E2 mediated DNA replication. Journal of Virology, 1;89(9):4980-91, 2015 PMC4403487
- E Langsfield, JM Bodily, and LA Laimins. The deacetylase Sirtuin 1 regulates human papillomavirus replication by modulating histone acetylation and recruitment of DNA damage factors NBS1 and Rad51 to viral genomes. PLoS Pathogens, 2015 Sep 25;11(9):e1005181. doi: 10.1371/journal.ppat.1005181, 2015. PMC4583417
- T Klymenko, H Hernandez-Lopez, A MacDonald, JM Bodily, and S Graham. Human papillomavirus E2 regulates SRSF3 (SRp20) to promote capsid protein expression in infected differentiated keratinocytes. 2016 Journal of Virology 90(10):5047-5058. PMC4859725 (Spotlighted as an Article of Significant Interest)
- SS Dykes, CF Gao, WK Songock, RL Bigelow, G Vande Woude, JM Bodily, and JA Cardelli. Zinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Sodium/Hydrogen Exchanger-1 (NHE1). Mol Carcinog. 2017 Feb;56(2):722-734. PMC5731239
- WK Songock, ML Scott, and JM Bodily. Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation. Virology. 2017 Apr 24;507:179-191. PMC5488730
- M. Bienkowska-Haba, W Luszczek, JE Myers, TR Keiffer, S DiGiuseppe, P Polk, JM Bodily, RS Scott, and M Sapp. A new cell culture model to genetically dissect the complete human papillomavirus life cycle. PLoS Pathog 2018 Mar 14(3): e1006846. (Highlighted Article) PMC5833277
- S Hong, S Cheng, W Songock, JM Bodily, and LA Laimins. Suppression of microRNA 424 levels by human papillomaviruses is necessary for differentiation-dependent genome amplification. Journal of Virology 2017 Nov 30, 91(24) e01712-17 PMC5709607
JT Guidry, J Meyers, M Bienkowska-Haba, WK Songock, X Ma, M Shi, CA Nathan, JM Bodily, M Sapp, R Scott. Inhibition of Epstein-Barr Virus Replication in Human Papillomavirus-Immortalized Keratinocytes. Journal of Virology 2019 93:e01216-18. https://doi.org/10.1128/JVI. PMC6321917
ML Scott, DT Coleman, KC Kelly, JL Carroll, BL Woodby, WK Songock, JA Cardelli, and JM Bodily. Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes. Virology 2018 Jun 30;519:1-11 PMC5971161
- BL Woodby, WK Songock, ML Scott, G Raikhy, and JM Bodily. Induction of interferon kappa in human papillomavirus type 16 infection by transforming growth factor beta-induced promoter demethylation. Journal of Virology Mar 2018 92(8):e01714-17. PMC5874427
- G Raikhy, ML Scott, BL Woodby, G Shin, JE Myers, RS Scott, and JM Bodily. Regulation of stromal gene expression by human papillomavirus type. Journal of Virology. 2019 Jul 10. pii: JVI.00458-19. doi: 10.1128/JVI.00458-19.
- JE Myers, JT Guidry, ML Scott, K Prasai, M Bienkowska-Haba, JM Bodily, MJ Sapp, Scott RS. Detecting episomal or integrated Human Papillomavirus 16 DNA using an Exonuclease V-qPCR-based assay. Virology. 2019 Aug 22;537:149-156.
- ML Scott, BL Woodby, J Ulicny, G Raikhy, AW Orr, WK Songock, and JM Bodily. Human papillomavirus type 16 E5 inhibits interferon signaling and supports episomal viral maintenance. J Virol. 2020 Jan 6;94(2)
- SM Rice, SM Kim, CM Rodriquez, WK Songock, G Raikhy, R Lopez, L Henderson, A Yusufji, and JM Bodily. Suppression of A Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via A Cyclin Dependent Kinase 8-Dependent Mechanism. Viruses 2020 Mar 13, 12:311
Postdocs: We are not actively recruiting postdoctoral fellows, but qualified candidates will be considered. Inquiries should be directed to Dr. Bodily firstname.lastname@example.org.
Graduate students: Students interested in working in our Department should visit our Graduate Program website: https://www.lsuhscshreveport.edu/departments/school-of-graduate-studies/microbiology-and-immunology/graduate-program
Undergraduate students: Our Undergraduate Biomedical Research Fellowship program provides bright undergraduates a chance to gain hands-on research experience through a paid internship. More information can be found here: https://www.lsuhscshreveport.edu/departments/school-of-graduate-studies/microbiology-and-immunology/undergraduate-fellowship