LSU Health Shreveport
Department of Cellular Biology & Anatomy
1501 Kings Hwy
Shreveport, LA 71103
Sumitra Miriyala, PhD
Assistant Professor of Cellular Biology and Anatomy
Master of Science, Biochemistry - University of Madras
PhD, Biochemistry and Cardiology - University of Madras
Post-Doctoral Fellow - University of Kentucky and Emory University
FAHA – American Heart Association
MBA - Louisiana State University Shreveport
Sudha Sharma presented “Role of 4-HNE in AIFm2 mediated retrograde stress signaling during Ischemia- reperfusion injury in heart” moderated poster at Industry Day held at LSU Health Shreveport on October 11, 2019.
Sudha Sharma gave oral presentation of “AIFm2 mediated retrograde stress signalling during ischemia-reperfusion injury in heart: Role of 4- HNE adduction” at Graduate Research Day held at LSU Health Shreveport, May 2019.
Sudha Sharma presented “AIFm2 mediated retrograde stress signalling during ischemia-reperfusion injury in heart: Role of 4- HNE adduction” Experimental biology held in Orlando, FL from April 6-9, 2019.
Alcohol-induced LPP3 suppression in brain endothelial cells leads to blood-brain barrier dysfunction. Experimental Biology – 2019 travel award to Ezar U Bess.
Congratulations to Drs. Panchatcharam, Miriyala, and Sun! Dr. Manikandan Panchatcharam (PI) and his co-investigators, Drs. Sumitra Miriyala and Hong Sun, were recently awarded an Administrative Supplement for the NIH grant entitled "Alcohol-Autotaxin-LPP3 Axis in Alzheimer's Disease Risk" from the National Institute of Alcohol Abuse and Alcoholism.
Congratulations to Dr. Miriyala! Dr. Miriyala was elected Fellow of the American Heart Association (FAHA) conferred by the Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB). Fellowship recognizes and awards premium professional members for excellence, innovative and sustained contributions in the areas of scholarship, practice and/or education, and volunteer service within the AHA/ASA.
Dr. Miriyala’s research involves evaluating prenatal genetic abnormalities of antioxidant enzymes, the mechanisms regulating gene expression. Her focus is to delineate the role of mitochondrial retrograde signaling with particular reference to oxidative modification of proteins in cerebral microcirculation. She is a PI and Co-Investigator on NIH R15, AAA, R01, R21, R25, and COBRE grants at LSU Health Shreveport.
Ongoing Research Support:
- R15HL141998-01 Miriyala (PI) NIH/NHLBI
04/2018 - 03/2021
Prenatal ethanol exposure alters lipid metabolism and cerebral microcirculation.
These studies' goal is to examine prenatal exposure of alcohol on lipid metabolism and cerebral microcirculation.
- R21AA025744-01A1 Panchatcharam (PI) Miriyala (Co-investigator), NIH/NIAAA
Alcohol-LPP3 axis in ischemic stroke
These studies' goal is to examine the influence of chronic alcohol consumption on brain LPP3 axis in ischemic stroke.
- R21AA025744-02S1 Panchatcharam (PI), Miriyala (Co-investigator) NIH/NIA
Alcohol-autotaxin-LPP3 axis in Alzheimer disease risk
These studies' goal is to examine the influence of chronic alcohol consumption on brain autotaxin- LPP3 axis in Alzheimer disease.
- AA023610-01A1 Sun (PI), Miriyala (Co-investigator),NIH/NIAAA
03/2016 - 02/2021
Light Alcohol Consumption and Ischemic Stroke
These studies' goal is to examine the influence of light alcohol consumption on brain injury following cerebral ischemia in adult rats/mice.
- P20GM121307-01A1 Kevil (PI), Miriyala (Co-investigator), NIH/NIGMS
02/2018 - 01/2023
Panchatcharam (Project leader) Lysolipid in heart failure development and progression
- P20GM121307-01A1 Kevil (PI), Miriyala (Project leader), NIH/NIGMS
02/2018 - 01/2023
AIFM2: A novel mediator of heart failure development and progression
- R15HL141998-01S1 Miriyala (PI), NIH/NIA
Alcohol-autotaxin-LPP3 axis in Alzheimer disease risk
These studies' goal is to examine the influence of chronic alcohol consumption on brain autotaxin- LPP3 axis in Alzheimer disease.
- R21AA026708-01A1 Panchatcharam (PI), Miriyala (Co-investigator), NIH/NIAAA
Alcohol mediated myocardial lysophosphatidic acid signaling
These studies' goal is to examine the influence of chronic alcohol consumption on the heart LPP3 axis in ischemic heart.
Completed Research Support:
- AAA-FGAP-5148 (American Association of Anatomists) 01/01/2018 -12/31/2018.
Doxorubicin alters myocardial lipid metabolism. Role: PI.
- Grant-in-Aid; LSUHSC-S Research Council 7/1/2013- 12/31/2015.
Role of LPP3 in the vasculature. Role: PI
- 10SDG4190036 (National Scientist Development Grant -American Heart Association)
Role: Co-Investigator. M Panchatcharam (PI) 07/01/10 - 06/30/15
Regulation of vascular cells and the arterial response to injury by LPP3.
- Diabetes Research and Action Education Foundation grant
Role: Co-Investigator. M Panchatcharam (PI) 01/01/13 - 06/30/14.
Multidrug resistance protein-1 (MRP-1) as an essential regulator of vascular inflammation and diabetic restenosis.
- UL1RR033173 (National Institutes of Health - National Center for Research Resources)
Role: Co-Investigator. M Panchatcharam (PI) 12/09/11 – 12/31/2012.
Functional validation of PPAP2B as a novel risk for coronary artery disease.
- 09BGIA2320011 (Beginning Grant in Aid - American Heart Association- Regional)
Role: Co-Investigator. M Panchatcharam (PI) 07/01/09 - 06/30/11.
Regulation of vascular cells and the arterial response to injury by LPP3
- Sumitra M, Manikandan P, Suguna L, Gopalan C. Study of dermal wound healing activity of Trigonella foenum graceum seeds in rats. J Clin Biochem Nutr 28:59-67, 2000. http://doi.org/10.3164/jcbn.28.59
- Sumitra M, Manikandan P, Kumar DA, Gayathri C, Arutselvan N, Manohar BM, Puvanakrishnan R. Experimental myocardial necrosis in rats: Role of arjunolic acid on platelet aggregation, coagulation, and antioxidant status. Mol Cell Biochem 224:135-142, 2001. (PMID: 11693190)
- Kumar DA, Manikandan P, Sumitra M, Narayana Raju KVS, Gayathri C, Arutselvan N, Puvanakrishnan R. A novel peptide derivative exhibits anti-inflammatory and antioxidant activity in adjuvant-induced arthritis in rats. Mol Cell Biochem 229: 9-17, 2002. (PMID: 11936851)
- Manikandan P, Sumitra M, Kumar DA, Gayathri C, Arutselvan N, Manohar BM, Puvanakrishnan R. Antioxidant potential of a novel tetrapeptide derivative in isoproterenol-induced myocardial necrosis in rats. Pharmacol 65: 104-110, 2002. (PMID: 11937781)
- Ravishankar, Manohar BM, Balachandran C, Sumitra M, Manikandan P, Puvanakrishnan R. Haemato-biochemical alterations and pathological changes in canine pyometra. Indian J Vet Pathol 28: 14-17, 2004. http://krishikosh.egranth.ac.in/handle/1/2057044?mode=full
- Sumitra M$, Manikandan P$, Kuppu Rao KV, Mohammed Nayeem, Manohar BM, Puvanakrishnan R. Cardiorespiratory effects of diazepam-ketamine, xylazine ketamine and thiopentone anesthesia in male Wistar rats - A comparative analysis. Life Sci 75, 1887-1896, 2004. (PMID: 15302232)
- Manikandan P, Sumitra M, Mohammed Nayeem, Manohar BM, Lokanadam B, Vairamuthu S, Subramaniam S, Puvanakrishnan R. Time course studies on the functional evaluation of experimental chronic myocardial infarction in rats. Mol Cell Biochem 267:47-58, 2004. (PMID: 15663185)
- Manikandan P, Sumitra M, Aishwarya S, Manohar BM, Lokanadam B, Puvanakrishnan R. Curcumin modulates free radical quenching in myocardial ischemia in rats. Int J Biochem Cell Biol. 36,1967-1980, 2004. (PMID: 15203111)
- Sumitra M, Manikandan P, Mohammed Nayeem, Manohar BM, Lokanadam B, Vairamuthu S, Subramaniam S, Puvanakrishnan R Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats. Mol Cell Biochem 268: 149-158, 2005. (PMID: 15724448)
- Sumitra M$, Manikandan P$, Suguna L. Efficacy of Butea monosperma on dermal wound healing in rats. Int J Biochem Cell Biol 37: 566-573, 2005. (PMID: 15618014)
- Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation. 113(24):2818-25; 2006 (PMID: 16769910)
- Panchatcharam M, Sumitra M, Gayathri VS, Suguna. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol Cell Biochem. L 290:87-96, 2006. (PMID: 16770527)
- Miriyala S, Panchatcharam M, Rengarajulu P. Cardioprotective effects of curcumin. Adv Exp Med Biol 595:359-377, 2007. (PMID:17569220)
- Smyth SS, Cheng HY, Miriyala S, Panchatcharam M, Morris AJ. Roles of Lysophosphatidic Acid in Cardiovascular Physiology and Disease. Biochim Biophys Acta 1781:563-570, 2008. (PMID: 18586114)
- Panchatcharam M, Miriyala S, Yang F, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in the regulation of vascular responses but not blood pressure. Circ Res. 103:662-670, 2008. (PMID: 18703779)
- Morris AJ, Panchatcharam M, Cheng HY, Federico L, Fulkerson Z, Selim S, Miriyala S, Escalante-Acalde D, and Smyth SS. Regulation of vascular cell function by bioactive Lysophospholipids. J Thromb Haemostasis, 7: 38-43, 2009. (PMID: 19630765)
- Sumitra M$, Manikandan P$, Gayathri VS, Mahendran P, Suguna L.. Emblica Officinalis exerts wound healing action through upregulation of collagen and extracellular signal-regulated kinases (Erk1/2). Wound Rep Reg, 17: 99-107, 2009.(PMID: 19152656)
- Meredith D$, Panchatcharam M$, Miriyala S, Tsai YS, Morris AJ, Maeda N, Stouffer GA and Smyth SS. Dominant-negative loss of function in PPARγ enhances smooth muscle cell proliferation, migration, and vascular remodeling. Arterioscler Thromb Vasc Biol 29:465- 471, 2009. (PMID: 19179641)
- Miriyala S, Subramanian T, Panchatcharam M, Ren H, Sunkara M. Drenan T, Smyth SS, Spielmann HP, and Morris AJ. Functional Characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates. J. Biol. Chem, 285:13918-29, 2010. (PMID: 20110354)
- Panchatcharam M, Miriyala S, Yang F, Wodnicka MC, Quilliam LA, Anaya P, Morris AJ, and Smyth SS. Enhanced proliferation and migration of vascular smooth muscle cells in response to vascular injury under hyperglycemic conditions is controlled by beta3 integrin signaling". Int J Biochem Cell Biol 42(6):965-74, 2010. (PMID: 20184965)
- Miriyala S, Holley AK, St Clair DK. Mitochondrial superoxide dismutase--signals of distinction. Anti-cancer agents in medicinal chemistry. 11(2):181-90; 2011(PMID: 21355846)
- Tangpong J, Miriyala S, Noel T, Sinthupibulyakit C, Jungsuwadee P, St Clair DK. Doxorubicin-induced central nervous system toxicity and protection by xanthone derivative of Garcinia mangostana. Neuroscience. 175:292-9; 2011. ( PMID: 21074598)
- Velez JM, Miriyala S, Nithipongvanitch R, Noel T, Plabplueng CD, Oberley T, Jungsuwadee P, Van Remmen H, Vore M, St Clair DK. p53 Regulates oxidative stress-mediated retrograde signaling: a novel mechanism for chemotherapy-induced cardiac injury. PloS one. 6(3):e18005; 2011. (PMID: 21479164)
- Aluise CD, Miriyala S, Noel T, Sultana R, Jungsuwadee P, Taylor TJ, Cai J, Pierce WM, Vore M, Moscow JA, St Clair DK, Butterfield DA. 2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain. Free radical biology & medicine. 50(11):1630-8; 2011. (PMID: 21421044)
- Evans AR, Miriyala S, St Clair DK, Butterfield DA, Robinson RA. Global effects of adriamycin treatment on mouse splenic protein levels. Journal of proteome research. 11(2):1054-64; 2012. (PMID: 22112237)
- Miriyala S, Spasojevic I, Tovmasyan A, Salvemini D, Vujaskovic Z, St Clair D, Batinic-Haberle I. Manganese superoxide dismutase, MnSOD, and its mimics. Biochimica et biophysica acta. 1822(5):794-814; 2012. (PMID: 22198225)
- Liu S, Bae Y, Leggas M, Daily A, Bhatnagar S, Miriyala S, St Clair DK, Moscow JA. Pharmacologic properties of polyethylene glycol-modified Bacillus thiaminolyticus thiaminase I enzyme. The Journal of pharmacology and experimental therapeutics. 341(3):775-83; 2012. (PMID: 22431205)
- Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The Janus of oxidative stress signaling in different pathophysiological conditions. Oxid Med Cell Longev 708796; 2013. (PMID: 23861992). *corresponding author
- Miriyala S, Panchatcharam M, Ramanujam M and Puvanakrishnan R. A novel tetrapeptide derivative exhibits in vitro inhibition of neutrophil derived reactive oxygen species and lysosomal enzymes release. Oxid Med Cell Longev. 853210; 2013. (PMID: 23819015). *corresponding author
- Panchatcharam M, Miriyala S, Salous A, Wheeler J, Dong A, Sunkara M, Escalante- Alcalde, Morris AJ, Smyth SS. Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation and limits neointimal hyperplasia. Arterioscler Thromb Vasc Biol.33 (1):52-9, 2013. (PMID: 23104851)
- Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer cell. 23(3):316-31; 2013.(PMID: 23453623)
- Miriyala S, Panchatcharam M, Landar A, Ramanujam M, Chatterjee S, Muthuswamy A. The janus of oxidative stress signaling in different pathophysiological conditions. Oxidative medicine and cellular longevity. 2013:708796;2013. (PMID: 23861992). *corresponding author
- Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, Noel T, Holley AK, Zhao Y, Kiningham KK, Clair DK, Clair WH. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer research. 73(14):4406-17; 2013. (PMID: 23674500)
- Mir SU, Schwarze SR, Jin L, Zhang J, Friend W, Miriyala S, St Clair D, Craven RJ. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy. 9(10):1566-78; 2013. (PMID: 24113030)
- Panchatcharam M, Salous A, Miriyala S, Wheeler J, Dong A, Sunkara M, Escalante- Alcalde, Morris AJ, Smyth SS. Mice with targeted inactivation of Ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability. Arterioscler Thromb Vasc Biol 34:837-845; 2014. (PMID: 24504738)
- Liu S, Miriyala S, Keaton MA, Jordan CT, Wiedl C, Clair DK, Moscow JA. Metabolic effects of acute thiamine depletion are reversed by rapamycin in breast and leukemia cells. PloS one. 9(1):e85702; 2014. (PMID: 24454921)
- Zhao Y, Miriyala S, Miao L, Mitov M, Schnell D, Dhar SK, Cai J, Klein JB, Sultana R, Butterfield DA, Vore M, Batinic-Haberle I, Bondada S, St Clair DK. Redox proteomic identification of HNE-bound mitochondrial proteins in cardiac tissues reveals a systemic effect on energy metabolism after doxorubicin treatment. Free radical biology & medicine. 72:55-65; 2014. (PMID: 24632380)
- Miriyala S, Chandra M, Maxey B, Day A, St. Clair DK, Panchatcharam M. Arjunolic acid ameliorates reactive oxygen species via inhibition of p47phox-serine phosphorylation and mitochondrial dysfunction. Int.J.Cell.Biol and Biochem 68:70-77; 2015. (PMID: 26319153)
- Chandra M, Panchatcharam M, and Miriyala S. Manganese Superoxide Dismutase: Guardian of the Heart. MOJ Anat Physiol 1(2):00006; 2015. (http://medcraveonline.com/MOJAP/MOJAP-01-00006.php). *corresponding author
- Suganya R, Chakraborty A, Miriyala S, Hazra TK, Izumi T. Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease. DNA repair. 27:40-8; 2015. (PMID: 25645679)
- Hayslip J, Dressler EV, Weiss H, Taylor TJ, Chambers M, Noel T, Miriyala S, Keeney JT, Ren X, Sultana R, Vore M, Butterfield DA, St Clair D, Moscow JA. Plasma TNF-α and Soluble TNF Receptor Levels after Doxorubicin with or without Co-Administration of Mesna-A Randomized, Cross-Over Clinical Study. PloS one. 10(4):e0124988; 2015. (PMID: 25909710)
- Xu Y, Miriyala S, Fang F, Bakthavatchalu V, Noel T, Schnell DM, Wang C, St Clair WH, St Clair DK. Manganese superoxide dismutase deficiency triggers mitochondrial uncoupling and the Warburg effect. Oncogene. 34(32):4229-37; 2015. (PMID: 25362851)
- Keeney JT, Miriyala S, Noel T, Moscow JA, St Clair DK, Butterfield DA. Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy. Cancer letters. 367(2):157-61; 2015. (PMID: 26225838)
- Chandra M, Fox J, Miriyala S and Panchatcharam M. Lipid phosphate phosphatase -3 and Its Role in Mitochondrial Function. MOJ Anat Physiol 2(1):00033; 2016. (http://medcraveonline.com/MOJAP/MOJAP-02-00033.php)
- Fox J, Chandra M, Panchatcharam M, and Miriyala S. Animal Models in Cardiovascular Diseases. MOJ Anat Physiol 2(1):00034; 2016. (http://medcraveonline.com/MOJAP/MOJAP-02-00034.php). *corresponding author
- Miriyala S, Thippakorn C, Chaiswing L, Xu Y, Noel T, Tovmasyan A, Batinic-Haberle I, Vander Kooi CW, Chi W, Abdel Latif A, Panchatcharam M, Prachayasittikul V, Butterfield DA, Vore M, Moscow J, St. Clair DK. Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. Free Radic Biol Med 91:68-80; 2016. (PMID: 26689472)
- Chandra M, Miriyala S, Panchatcharam M. PPARγ and Its Role in Cardiovascular Diseases. PPAR Res 6404638; 2017. (PMID: 28243251)
- Jackson KL, Lin WL, Miriyala S, Dayton RD, Panchatcharam M, McCarthy KJ, Castanedes-Casey M, Dickson DW, Klein RL.p62 Pathology Model in the Rat Substantia Nigra with Filamentous Inclusions and Progressive Neurodegeneration. PLoS One 12(1):e0169291; 2017. (PMID: 28076378)
- Sreedhar A, Lefort J, Petruska P, Gu X, Shi R, Miriyala S, Panchatcharam M, Zhao Y. UCP2 upregulation promotes PLCγ-1 signaling during skin cell transformation. Mol Carcinog. 56(10):2290-2300; 2017.(PMID: 28574619)
- Alam S, Abdullah CS, Aishwarya R, Orr AW, Traylor J, Miriyala S, Panchatcharam M, Pattillo CB, Bhuiyan MS. Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes. Biosci Rep 37(4). pii: BSR20170898; 2017. (PMID: 28667101)
- Sreedhar A, Petruska P, Miriyala S, Panchatcharam M, Zhao Y.UCP2 overexpression enhanced glycolysis via activation of PFKFB2 during skin cell transformation. Oncotarget 8(56):95504-95515; 2017.(PMID: 29221144)
- Chandra M, Escalante-Alcalde D, Bhuiyan MS, Orr AW, Kevil CG, Morris AJ, Nam H, Dominic P, McCarthy KJ, Miriyala S*, Panchatcharam M. Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure. Redox Biology 14, 261-271; 2018. (PMID: 28982073). *corresponding author
- Alam S, Abdullah CS, Aishwarya R, Miriyala S, Panchatcharam M, Peretik JM, Orr AW, James J, Robbins J, Bhuiyan MS. Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity. Journal of the American Heart Association. 2018; 7(14). (PMID: 29987122)
- Abdullah CS, Alam S, Aishwarya R, Miriyala S, Panchatcharam M, Bhuiyan MAN, Peretik JM, Orr AW, James J, Osinska H, Robbins J, Lorenz JN, Bhuiyan MS. Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics. Journal of the American Heart Association. 7(20):e009775; 2018. (PMID: 30371279)
- Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA. The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α. Free radical biology & medicine.134:1-8; 2018. (PMID: 30593843)
- Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, Bhuiyan MS. Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Scientific reports. 9(1):2002; 2019.(PMID: 30765730)
- Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L.Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells. Redox Biol. 16;26:101220: 2019.(PMID: 31176262)
- Ren X, Keeney JTR, Miriyala S, Noel T, Powell DK, Chaiswing L, Bondada S, St Clair DK, Butterfield DA.The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α. Free Radic Biol Med. 134:1-8; 2019. (PMID: 30593843)
- Aishwarya R, Alam S, Abdullah CS, Morshed M, Nitu SS, Panchatcharam M, Miriyala S, Kevil CG, Bhuiyan MS. Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytes. Redox Biol . 2020 Jul 26;36:101660. doi: 10.1016/j.redox.2020.101660 (PMID: 32750667)
- Sharma S, Bhattarai S, Ara H, Sun G, St. Clair DK, Kevil CG, Watts MN, Dominic P, Shimizu T, Bhuiyan MS, McCarthy KJ, Sun H, Panchatcharam, Miriyala S*. SOD2 deficiency in cardiomyocytes defines defective mitochondrial bioenergetics as a cause of lethal dilated cardiomyopathy. Redox Biology (in press https://www.sciencedirect.com/science/article/pii/S2213231720309459) (PMID: 33049519 *corresponding author
- Alam S, Abdullah CS, Aishwarya R, Morshed M, Nitu SS, Miriyala S, Panchatcharam M, Kevil CG, Orr AW, Bhuiyan MS. Dysfunctional mitochondrial dynamic and oxidative phosphorylation precedes cardiac dysfunction in R120G-αB-crystallin induced desmin-related cardiomyopathy. Journal of the American Heart Association (Accepted - In Press JAH35669 Article DOI: 10.1161/JAHA.120.017195)
- Abdullah CS, Aishwarya R, Alam S, Morshed M, Remex NS, Nitu SS, Sadia Nitu1, Kolluru GK, Traylor J, Miriyala S, Panchatcharam M, Hartman B, King J, Bhuiyan MAN, Chandran S, Woolard MD, Yu X, Goeders NE, Paari D, Arnold CL, Stokes K, Kevil CG, Orr AW, Bhuiyan MS. Methamphetamine induces cardiomyopathy by Sigmar1 inhibition dependent impairment of mitochondrial dynamics and function . Nature - Communication Biology (COMMSBIO-20-0906-T – Resubmitted - Minor Corrections - Under review)
Complete List of my Published Work in MyBibliography: LEARN MORE
Sudha received a BS (2011) and MS (2014) from Kathmandu University. She worked as a lecturer in Manipal College of Medical Sciences, Pokhara, Nepal. She joined LSU Health Shreveport in the Department of Cellular Biology & Anatomy as a Graduate student in August 2017.
Sudha is a 3rd-year graduate student in Dr. Miriyala’s lab. She currently studies ischemia-reperfusion in the cardiomyocyte-specific knock-out mice of manganese superoxide dismutase. She is looking at the mitochondrial dysfunction and change in the bioenergetics profile due to oxidative stress in the heart.
Dr. Alotaibi is originally from Saudi Arabia. Dr. Alotaibi obtained his Doctor of Dental Surgery degree from King Saud University at Riyadh, Saudi Arabia in 2010. Then, he moved to the United States and completed Oral and Maxillofacial Surgery Internship and Residency programs at Jackson Memorial Hospital/ University of Miami 2013-2018. Following graduation from residency, he completed two years fellowship in Head and Neck Oncologic / Microvascular Reconstructive Surgery at LSU Health Shreveport in 2020. He is certified with the American Board of Oral & Maxillofacial Surgery (ABOMS) since March 2020. Today, Dr. Alotaibi serves as Assistant Professor of Oral & Maxillofacial Surgery at LSU Health Shreveport with a special interest in Head and Neck Oncology, Microvascular Reconstruction, facial trauma, Osteoradionecrosis, Medication-Related Osteonecrosis of Jaw (MRONJ), Orthognathic surgery, dental implants, and dentoalveolar surgery. When not busy with his career, he enjoys watching and playing soccer, spending time with his wife, Joza, and their daughters, Joud & Joory.
Dr. Alotaibi is a 1st-year graduate student in Dr. Miriyala’s lab. He currently studies prenatal genetic abnormalities of antioxidant enzymes, the mechanisms regulating gene expression. His focus is to delineate the role of retrograde mitochondrial signaling with particular reference to oxidative modification of proteins in cerebral microcirculation.
Samantha is a graduate student at LSU Health Shreveport. She is originally from Champaign, IL. She completed her undergrad at Illinois State University in Bloomington, IL. She graduated with a Bachelor of Science in General Biology. She moved to Shreveport, LA in 2018 and is currently pursuing becoming a Physician Assistant and looking forward to applying in Spring 2021! She has gained a lot of medical experience since graduating undergrad, from being a pharmacy technician, medical assistant, Newborn hearing screener, and Emergency Department scribe. In her last year of undergrad, she was given the fantastic opportunity to work under Dr. Andres G. Vidal Gadea with research regarding Duchenne Muscular Dystrophy. She worked with her mentor Angelica regarding intracellular calcium dysregulation that precedes muscle decline in C. elegans, which model Duchenne Muscular Dystrophy. When she started grad school this fall, she was given another amazing opportunity to work in Dr. Miriyala’s lab. The knowledge she has gained since starting is something that she knows she will carry on to her future endeavors. Some hobbies she has outside of academia are singing, playing with her dog, and going on outdoor adventures! She is very excited to see what the future holds in Dr. Miriyala’s Lab!