SUB-PROJECTS | CPTR
Sub-Project 1
Decoding lncRNA-mediated Gene Regulation During Nutrient Metabolism
Tarek Magdy Mohamed, PharmB, PhD
Assistant Professor, Department of Pathology and Translational Pathobiology
Dr. Magdy is an expert in single nucleotide polymorphism analysis to uncover their role in regulating cell phenotype, focusing on the genomics of cardiometabolic disease using cell models derived from human iPSCs15-19. In addition, he adopts state-of-the-art techniques, including somatic cell reprogramming into human iPSCs, multi-lineage iPSC differentiation, CRISPR/Cas9-mediated functional genomics methods, multi-omics approaches, and bioinformatics.
Sub-Project 2
Polyamine-Dependent RNA Stability & Protein Translation in Hepatocytes
Arif Yurdagul, PhD
Associate Professor, Department of Molecular and Cellular Physiology
Dr. Yurdagul has extensive expertise in studying polyamine metabolism, post-transcriptional regulatory mechanisms, hepatocyte function, and omics-based approaches over the past decade15, 20-23. He has led research that integrates molecular biology, advanced genetic models, and cutting-edge sequencing technologies to uncover critical pathways in cellular homeostasis.
Sub-Project 3
Glycolytic Regulation of Post-translational Modifications in Hepatocyte Homeostasis
Nirav Dhanesha, PhD
Assistant Professor, Department of Pathology and Translational Pathobiology
Employing advanced genetic models, omics platforms, and mechanistic assays, Dr. Dhanesha has uncovered metabolic triggers linking hepatocyte glycolysis to systemic coagulopathy. His recent work in hepatocyte biology explores liver-specific hypercoagulability and inflammation using in vitro hepatocyte cultures and transcriptomic approaches.