News from LSU Health Shreveport

DNA Damage Viewed with Unprecedented Clarity

Xiao-Hong Lu, Associate Professor of Pharmacology, Toxicology and Neuroscience at LSU Health Shreveport, found that many existing tools for probing DNA damage rely on cell replication pathways not present in neurons. “We cannot directly use those methods,” he says, so he made his own, “a sensor specifically for the brain.” 

Lu’s genetic sensor, called PRISM (Probe with a viRal proxy for the Instability of DNA surveillance/repair in Somatic brain Mosaicism), uses a viral vector to flag cells that have initiated their DNA damage response (DDR), a set of signaling cascades that regulate DNA repair and cell-cycle checkpoints following genotoxic stress. 

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