News from LSU Health Shreveport

3D printing molds for CAD designs, Stents, Cells

We are excited to announce that the paper "3D Printing for Bio-Synthetic Biliary Stents" is nominated for the 2020 Best Paper
Award from Bioengineering journal to be announced in December, 2020.

The award will be granted to the papers published in 2019 and each of the winners will receive a Prize of 500 CHF and a certificate for “2020 Best Paper in Bioengineering”. One review paper and two research articles will be the winners.

Authors: Christen J. Boyer, Moheb Boktor, Hrishikesh Samant, Luke A. White, Yuping Wang, David H. Ballard, Robert C. Huebert, Jennifer E. Woerner, Ghali E. Ghali,  and Jonathan S. Alexander

Abstract

Three-dimensional (3D) printing is an additive manufacturing method that holds great potential in a variety of future patient-specific medical technologies. This project validated a novel crosslinked polyvinyl alcohol (XL-PVA) 3D printed stent infused with collagen, human placental mesenchymal stem cells (PMSCs), and cholangiocytes. The biofabrication method in the present study examined 3D printing and collagen injection molding for rapid prototyping of customized living biliary stents with clinical applications in the setting of malignant and benign bile duct obstructions. XL-PVA stents showed hydrophilic swelling and addition of radiocontrast to the stent matrix improved radiographic opacity. Collagen loaded with PMSCs contracted tightly around hydrophilic stents and dense choloangiocyte coatings were verified through histology and fluorescence microscopy. It is anticipated that design elements used in these stents may enable appropriate stent placement, provide protection of the stent-stem cell matrix against bile constituents, and potentially limit biofilm development. Overall, this approach may allow physicians to create personalized bio-integrating stents for use in biliary procedures and lays a foundation for new patient-specific stent fabrication techniques.

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