News from LSU Health Shreveport

Dr. Witt Awarded R15 AREA Grant

Dr. Stephan N. Witt was awarded an R15 AREA grant entitled, “The role of alpha-synuclein in Snx3-retromer mediated recycling of membrane proteins.” The grant provides Dr. Witt with $100,000 per year each year for three years. The total direct and indirect costs are $438,000. This grant will begin 1 December 2018.

Background/Goals of This Grant:
The R15 grant follows up on a discovery made by then-graduate student Dhaval Patel that the Parkinson’s disease protein alpha-synuclein disrupts Snx3-retromer mediated recycling of the iron transport complex Fet3-Ftr1. This finding was recently reported in Human Molecular Genetics. The R15 grant seeks to deepen our understanding about how alpha-synuclein blocks the binding of phox homology domain-containing proteins to phosphatidylinositol 3-phosphate.

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